The Senna Hair Lab studies hair and scalp disorders and how best to treat them. We run industry sponsored trials and our own studies in clinic. We also analyze large sets of real world patient data.
Research
Clinical trials
Industry and investigator led studies of new treatments for alopecia areata, lichen planopilaris, and other hair disorders.
Webinars and media
Patient education from Dr. Senna, including articles for Harvard Health Publishing and posts on Instagram.
Research fellowship
A research year for medical students. Fellows work in clinic, help run trials and write their own papers.
Research areas
Alopecia areata
We study how patients respond to JAK inhibitors in everyday practice, including what happens when they switch drugs or change doses. Recent work: switching JAK inhibitors and tofacitinib dose escalation.
Scarring alopecias
We run trials and cohort studies in lichen planopilaris, frontal fibrosing alopecia and CCCA. Recent work: delgocitinib cream in FFA and hairline stability in FFA. Dr. Senna also served on the expert panel for national consensus recommendations on CCCA treatment.
New therapies
We enroll patients in industry sponsored trials and lead our own studies of emerging treatments. See our current clinical trials.
Drug safety
We track hair loss linked to medications and supplements, and the safety of common hair loss treatments. Recent work: finasteride and dutasteride and breast and gynecologic cancer risk in women, oral minoxidil dosing and liver injury from turmeric supplements.
Access and equity
We study what hair loss care costs patients and how cost shapes treatment. Recent work: the financial burden of scarring alopecia.
Patient education
We write plain language guides and explain new research to the public. Read our hair loss conditions guide or see Dr. Senna in the media.
Recent publications
- Randomized controlled trial of the topical JAK inhibitor delgocitinib cream in patients with frontal fibrosing alopecia
Martin A, et al. · J Invest Dermatol, 2026 · PMID 41101628 - Switching between Janus kinase inhibitors for treatment of alopecia areata: a multicenter retrospective review
Martin A, et al. · J Am Acad Dermatol, 2026 · PMID 41621668 - Long-term stability of hairline landmarks in treated frontal fibrosing alopecia: a retrospective cohort study
Ezzat RZ, et al. · JAAD Int, 2026 · PMID 42027989 - Hormonal associations in frontal fibrosing alopecia: a systematic review
Ezzat RZ, et al. · JAAD Int, 2026 · PMID 42306340 - Rethinking oral minoxidil: distinguishing the hair growth window from the cardiovascular threshold
Ezzat RZ, et al. · J Am Acad Dermatol, 2026 · PMID 41887575 - Financial burden of scarring alopecia: insights from the Cicatricial Alopecia Patient Assessment and Impact Report
Spindler A, et al. · Skin Appendage Disord, 2026 · PMID 41884151 - Coexistence of cicatricial alopecia and alopecia areata: a case series
Paz M, et al. · JAAD Case Rep, 2026 · PMID 42282919 - The dose matters: oral tofacitinib dose escalation or switching to deuruxolitinib for recalcitrant alopecia universalis and totalis
Ezzat RZ, et al. · JAAD Case Rep, 2026 · PMID 42404728